Diovan

Diovan is an antihypertensive medication (indicated for therapy of great pressure). The medication is an angiotensin II receptor villain. By acting on these receptors, Diovan blocks the action of angiotensin II, thereby decreasing high blood pressure.


Indications

High high blood pressure (arterial hypertension).
Chronic center failing (functional class II-IV) together with other medication.
Postinfarction state.
Side effects

Diovan is generally well accepted, and its side effects are unusual. The side effects of Diovan do not depend on the duration of therapy, sex or race.

The following are among the common part effects:

Significant decrease in stress when instantly changing the body system position from horizontal to vertical.
Dizziness.
Taking Diovan improves the chance of neutropenia (abnormally low variety of neutrophils in the blood).
When getting Diovan, there were improved occurrence of attacks recorded
Rare part effects

Disorders of the respiratory system: there may be dry coughing, but the frequency of this symptom for angiotensin II receptor antagonists (including Diovan) is less than for ACE inhibitors.

Disorders of the cardio-vascular system: extended decrease in high blood pressure, especially in the evenе of an over dose. In sufferers that suffered myocardial infarction, Diovan may cause devastation of the center operate, and edemas. There is possible development of vasculitis (inflammation of blood veins vessels).

Disorders of the defense mechanisms and the skin: allergy, itchiness, swelling of the epidermis, abnormal thinning hair. There are situations of skin psoriasis.

Disorders of the gastro-intestinal tract: diarrhoea or bowel problems, nausea or vomiting, dry mouth, heartburn, abdominal pain, appetite reduction, nausea or vomiting, unwanted gas, taste conditions. There are possible inflamation related changes in the liver organ, and a rise in blood veins stages of liver organ minerals.

Disorders of the bone and joint system: joint problems, muscular discomfort, back discomfort, muscle spasms, separated situations of devastation of muscular mass.

Disorders of the kidney: kidney harm, acute kidney failing, which is demonstrated in the form of an advanced level of creatinine, urea nitrogen, and blood potassium in the blood veins.

Disorders of the central nervous system: may cause complications, sleeplessness or sleepiness, weak point, exhaustion, anxiety. Sometimes, there may be passing out. The patient may experience pins and needles, prickling, “pins and needles”.

Low libido may also occur. Nosebleeds are possible.

Serious part effects

Patients with personal intolerance may create serious allergies such as angioedema (Quincke’s edema). The probability of angioedema appearing is higher in people who had similar responses to other medication in the past. Very great stages of blood potassium in the blood veins can cause to serious cardiac arrhythmias.

Changes in clinical parameters

In unusual situations, the use of Diovan may cause to unusually low focus of hemoglobin, hematocrit and platelets in the blood veins. Diovan improves the chance of hemolytic anemia (intensive devastation of erythrocytes). There may be a important decrease in the variety of neutrophils, thereby decreasing the body resistance to attacks. There are possible improves in the stages of creatinine, urea nitrogen, blood potassium, total bilirubin, and liver organ minerals in blood veins serum. The stages of liver organ minerals come back to regular when the medication is removed. Diovan has no effect on the level of cholesterol, triglycerides, blood veins sugar, or the crystals.

Contraindications

Hypersensitivity to any ingredient component of the medication.
Pregnancy.
Breast-feeding.
Side results during maternity and breast-feeding

The medication is contraindicated for maternity and women planning to get pregnant. Diovan has an FDA maternity category D. Using of the medication in the second and third trimester of maternity causes baby harm and death. When used in the first trimester of maternity, Diovan improves the chance of having a baby to kids with delivery problems. There is evidence of natural abortion, little bit of amniotic liquid and kidney malfunction in babies whose mothers received Diovan during maternity. Diovan is most likely to pass into the breasts dairy. Therefore, this medication should not be used during breast-feeding.

Side results in children

The medication is approved for the therapy of high blood pressure in kids and youngsters outdated 6-18 years. Side results in kids are the same with those in adults.

Overdose

Overdose symptoms include serious decrease in high blood pressure, which can cause to affected awareness, life-threatening condition with devastation of blood veins flow to vital organs. Shock may create.

Cautions

Patients with affected kidney function

Dosage modification is not required in sufferers with affected kidney operate, but the medication must be used with greater warning. The medication should be used with warning in sufferers with kidney artery stenosis or artery stenosis of individual kidney, and sufferers that experienced kidney implant. These sufferers may have great stages of urea and creatinine in the blood veins, which come back to regular stages after stopping of the medication. These signs need regular clinical tracking. There is no data on the safety of the medication for sufferers undergoing hemodialysis.

Patients with affected liver organ function

Patients with liver organ illnesses should not take Diovan in great dose, as its focus in the blood veins may improve significantly. The medication should be taken with additional care in sufferers with liver organ failing who have biliary impediment or cholestasis.

Effects on the automotive abilities or work with dangerous machinery

Patients getting Diovan should be careful when operating equipment and driving a car prior to determining the person reaction to the medication.

At the beginning of therapy, high blood pressure may significantly lower in sufferers with serious deficiency of salt and/or blood veins volume in the body system (such as sufferers with excessive nausea or vomiting and diarrhea), in sufferers getting great dosage of diuretics, and in sufferers under a salt-free diet.