Digoxin
Digoxin is a heart glycoside produced from the results in of digitalis lanata (often known as the Woolly Foxglove or Grecian Foxglove).
Digoxin prevents the compound that is included in the cell surfaces of the center, thereby improving the focus of calcium mineral in the tissues, which brings in turn to increased contractility of myocardial tissues as myocardium is the center muscular that can contract and relax. With a more powerful center muscular shrinkage, the center ejects wide range of blood vessels, which should be obtained when the contractile function of the center is damaged. This is known as a cardiotonic impact, which is required in sufferers with center failing. Helping the focus of calcium mineral in center tissues, Digoxin also impacts the pulse amount. The time of center “rest” after its shrinkage improves, thereby reducing the pulse amount. Digoxin impacts the transmission of sensors signals to the center muscular by reducing it doen. Thus, when there is a interruption in the beat, that happened in the transmission program of the auricle and combined with a distinct improve in pulse amount, Digoxin can slowly the transmission of sensors reaction and recover regular pulse amount. Digoxin has a light diuretic impact, because it improves kidney blood vessels circulation.
Indications
chronic blood circulation failing of I-IIA, IIB and III degree, due to myocardial contractility disorder (dilated cardiomyopathy, aterosclerotic cardiosclerosis, etc. – without hemodynamically significant impediment of the output system of the heart);
paroxysmal supraventricular tachyarrhythmias (atrial fibrillation, atrial flutter, paroxysmal supraventricular tachycardia);
conversion of atrial flutter or atrial fibrillation to nasal area rhythm;
in childrens sufferers – all types of center failing, combined with tachycardia and demanding fast digitalization.
Side effects
Disorders of the intestinal system: nausea or nausea, nausea, diarrhoea, stomach pain, anorexia (refusing to eat due to distinct loss of appetite).
Disorders of the anxious system: frustration, wooziness, exhaustion, sleeplessness or sleepiness, depressive disorders, misunderstandings, hallucinations.
Disorders of the heart system: infrequent pulse rate, incapacity of sensors transmission in the center (AV-block), serious bradycardia (abnormally slowly pulse rate less than 60 per minute), ventricular early surpasses (appearance of early contractions of the heart).
Eye disorders: double perspective, playful of goes before the eyes, light level of sensitivity, affected color understanding, reduced visible skill, macropsia or micropsia (visual conditions, in which things are recognized more/less than they really are), scotoma (blind spot in an otherwise regular visible field).
Blood disorders: petechiae (red spots due to blood loss into the skin), thrombocytopenia (abnormally low blood vessels platelet counts), nasal area blood loss.
Allergic reactions: itchiness, cities.
Others: man boobs (breast augmentation in men) under a extended use, hearing ringing, pins and needles of mouth, nasal area, face, hearing.
Serious part effects
Glycoside inebriation is a serious, and sometimes critical, side-effect. The deadly amount for most heart glycosides is only 5-10 periods greater than the minimum efficient amount and only 2 periods greater than the amount that results in the first signs of inebriation. In serious situations, there may be life-threatening irregularities in center beat (arrhythmia), or total blood circulation police arrest. In such situations, the only efficient remedy is anti-Digoxin applied intravenously.
Laboratory abnormalities
thrombocytopenia (abnormally low blood vessels platelet counts)
hypokalemia (abnormally low level of blood potassium in the blood)
Side results during maternity and breast-feeding
Digoxin has an FDA maternity classification C.
This treatment can go through through the placenta. It is discovered in the blood vessels of the unborn infant in the same levels as in the expectant mother. It goes into breasts dairy in small amounts. However, women who are at the same time getting Digoxin and breast-feeding should regularly observe their kid's pulse amount. There were no teratogenic results (negative impact on baby development) discovered in scientific tests. However, Digoxin is taken in maternity only when the benefits of getting it surpass the danger to the unborn infant or child.
Side results in the elderly
The seniors often have concomitant coronary heart with atherosclerotic coronary heart. Therefore, angina may intensify, or the person's state decline. This is due to a rise in heart stroke volume and in myocardial fresh air demand, which is removed using antianginal drugs from the group of calcium mineral ion antagonists.
Side results in children
In childrens medicine, Digoxin is used in sufferers with center failing, combined with tachycardia and demanding fast digitalization. The amount is determined independently based on the kid's weight. Kids may experience all of these adverse responses of Digoxin. However, the kid's condition should be totally supervised during therapy with Digoxin.
Overdose
Symptoms: A variety of arrhythmias, partially or complete atrioventricular prevent, blurry perspective, exhaustion, muscular weak point, dyspepsia, nausea, nausea or nausea, and mental conditions.
In the case of poisoning due to the treatment over dose during a necessary long-term therapy with the treatment, make a break for a length that relies on the degree of the scientific picture of inebriation.
Warnings and recommendations
The use of Digoxin requires additional care in performing all the physician's suggestions regarding management rules. The treatment connected to the type of harmful ingredients, and therefore any changes in dose not decided with the doctor can lead to very serious repercussions (worsening of the illness or intoxication).
