Vicodin
Relates to acetaminophen / hydrocodone: dental product, dental elixir, dental fluid, dental remedy, dental tablet
Get emergency healthcare help if you have any of these signs of an level of sensitivity while taking acetaminophen / hydrocodone: hives; difficulty breathing; inflammation of your face, mouth, mouth, or throat.
Call your physician at once if you have any of these serious part effects:
shallow respiration, slow heartbeat;
feeling light-headed, fainting;
confusion, fear, uncommon thoughts or behavior;
seizure (convulsions);
problems with urination; or
nausea, upper abdomen discomfort, itchiness, appetite loss, dark pee, clay-colored chairs, jaundice (yellowing of the epidermis or eyes).
Less serious negative reactions of acetaminophen / hydrocodone may include:
anxiety, wooziness, drowsiness;
mild nausea or nausea, nausea, disappointed abdomen, constipation;
headache, feelings changes;
blurred vision;
ringing in your ears; or
dry oral cavity.
This is not a complete list of negative reactions and others may occur. Contact your physician for healthcare health advice about negative reactions.
For Healthcare Professionals
Applies to acetaminophen / hydrocodone: dental product, dental elixir, dental fluid, dental remedy, dental tablet
General
The part results of hydrocodone are usually similar to the part results noticed with other narcotic discomfort killers. Acetaminophen is usually well-tolerated when applied in healing dosage.
Nervous system
One research has recommended that the respiration depressive disorders due to hydrocodone may be of benefit in the treatment of dyspnea relevant to serious obstructive lung illness and limited lung illness. However, the potential for the rainfall of respiration inadequacy makes such use of hydrocodone dangerous and such use should be performed, if at all, only with alert.
Nervous program negative reactions of hydrocodone consist of mental depressive disorders, wooziness, faintness, respiration depressive disorders (which is sometimes fatal), stupor, delirium, somnolence, frustration, and dysphoria.
Other
Other negative reactions have involved drawback signs, after either unexpected cessation or fast declining of narcotic discomfort killers. Such signs may consist of frustration, uneasiness, stress, sleeplessness, tremor, abdominal pain, blurry perspective, nausea, and sweating.
Hepatic
Alcoholic sufferers may develop hepatotoxicity after even moderate dosage of acetaminophen. In healthy sufferers, approximately 15 grms of acetaminophen is necessary to wipe out liver organ glutathione stores by 70% in a 70 kg person. However, hepatotoxicity has been revealed following smaller dosage. Glutathione levels may be repleted by the remedy N-acetylcysteine. One situation report has recommended that hypothermia may also be beneficial in reducing liver organ damage during over amount.
In a recent retrospective research of 306 sufferers confessed for acetaminophen over amount, 6.9% had serious liver organ injury but all retrieved. None of the 306 sufferers passed away.
A 19-year-old female developed hepatotoxicity, sensitive plasmacytosis and agranulocytosis followed by a leukemoid response after serious acetaminophen poisoning.
The part results of hydrocodone may be more likely and more serious in sufferers with liver organ illness.
Hepatic negative reactions such as serious and sometimes critical amount dependent liver disease have been revealed in addict sufferers. Hepatotoxicity has been improved during going on a fast. Several situations of hepatotoxicity from serious acetaminophen therapy at healing dosage have also been revealed despite a lack of risks for poisoning.
Gastrointestinal
Gastrointestinal negative reactions with the use of acetaminophen are uncommon except in alcoholics and after over amount. Installments of serious pancreatitis have been revealed hardly ever.
Gastrointestinal complication such as nausea or nausea, nausea, bowel problems, and xerostomia area are relatively common results of narcotic discomfort killers.
One research has recommended that acetaminophen may precipitate serious biliary discomfort and cholestasis. The procedure of this impact may be relevant to self-consciousness of prostaglandin and modifications in the control of the sphincter of Oddi.
Genitourinary
Genitourinary negative reactions such as ureteral spasm, spasm of vesicle sphincters, and urinary storage have been revealed.
Dermatologic
Dermatologic negative reactions such as narcotic-induced epidermis rashes have been revealed. Common erythematous epidermis rashes associated with acetaminophen have been revealed, but are uncommon. A uncommon situation of bullous erythema associated with acetaminophen has been revealed.
Renal
Renal negative reactions of acetaminophen are uncommon and consist of serious tubular necrosis and interstitial nephritis. Adverse kidney results are most often noticed after over amount, from serious misuse (often with multiple analgesics), or in association with acetaminophen-related hepatotoxicity.
Acute tubular necrosis usually occurs together with liver organ failure, but has been noticed as an separated finding in uncommon situations.
The part results of hydrocodone may be more likely and more serious in sufferers with kidney inadequacy.
Hematologic
Hematologic negative reactions such as uncommon situations of thrombocytopenia associated with acetaminophen have been revealed. Acute thrombocytopenia has also been revealed as having been due to level of sensitivity to acetaminophen glucuronide, the major metabolite of acetaminophen. Methemoglobinemia with resulting cyanosis has also been seen in the setting of serious over amount.
Hypersensitivity
Hypersensitivity negative reactions to acetaminophen have been revealed hardly ever.
Respiratory
Respiratory negative reactions have involved a situation of eosinophilic pneumonia which has been associated with acetaminophen.
Metabolic
In the situation of metabolic acidosis, causality is unclear as more than one drug was consumed. The situation of metabolic acidosis followed the intake of 75 grms of acetaminophen, 1.95 grms of pain killers, and a bit of a fluid household cleaner. The affected person also had a history of drawback leading to convulsions which the writers revealed may have provided to an improved lactate level a sign of metabolic acidosis.
Metabolic negative reactions such as metabolic acidosis have been revealed following a massive over amount of acetaminophen.
