Acyclovir

Acyclovir  (or Aciclovir) is an antiviral medication. Acyclovir  is mainly used for the therapy of vaginal herpes attacks (herpes simplex malware 1 and 2), as well as in the therapy of varicella zoster malware, Epstein-Barr malware and cytomegalovirus.


Viruses are intra cellular harmful bacteria, which have their own DNA, and recreate by regularly duplicating their DNA and duplicating all other components of the malware. Acyclovir  is included in the DNA of the malware and stops further development of the malware with no damage the human tissues.

Indications

Indications for wide spread therapy: main and repeated attacks of the epidermis and mucous walls due to the vaginal herpes (type 1 and 2), which include vaginal herpes, vaginal herpes zoster, and chickenpox. Acyclovir  is used in a mixture therapy in sufferers with serious immunosuppression (such as sufferers with HIV infection) and in sufferers that experienced cuboid marrow hair transplant, as well as for avoidance of cytomegalovirus illness after cuboid marrow hair transplant.

Indications for exterior therapy: vaginal herpes simplex of the epidermis and mucous walls, vaginal herpes (primary and recurrent); nearby vaginal herpes zoster (support therapy).

Indications for external therapy in ophthalmology: herpetic keratitis.

Side effects

Systemic therapy:

Digestive program disorders: nausea or nausea, nausea, diarrhoea, stomach discomfort, anorexia (abnormal hunger loss for food, especially as a result of disease).

Nervous program disorders: wooziness, frustration, nausea or nausea, sleepiness, misunderstandings, hallucinations, convulsions, trembling (shaking), depressive disorders or psychosis (neurological conditions usually seen in sufferers with actual mental states).

Blood program conditions (observed when the medication is treated intravenously): anemia (a lack of red blood vessels tissues or of hemoglobin in the blood), neutropenia (presence of unusually few neutrophils in the blood) or neutrophilia (presence of unusually great neutrophils in the blood), thrombocytopenia (abnormally low variety of platelets in the blood) or thrombocytosis (abnormally large variety of platelets in the blood) or leukocytosis (abnormally great white blood vessels cell count), DIC (disseminated intravascular coagulation), hemolysis (destruction of red blood vessels cells).

Cardiovascular program disorders: lower hypertension.

Genitourinary program disorders: short-term (temporary) improve in blood vessels urea nitrogen and serum creatinine stages, serious renal failing (often happens under fast medication injection), hematuria (presence of blood vessels in urine).

Other reactions: myalgia (pain in a muscle or group of muscles), paresthesia (abnormal emotions, such as losing, prickling, or a “pins-and-needles” feeling at various sites), hair loss, epidermis allergies (pruritus, allergy, urticaria), affected perspective, high temperature, lymphadenopathy (swollen lymph nodes), side-line inflammation, responses at the medication hypodermic injection site: phlebitis or local inflammation (pain, inflammation or redness), necrosis (when the medication goes into under the skin).

Severe hypersensitive reactions: anaphylaxis, Lyell’s problem.

External therapy:

Skin and mucous membranes: discomfort, losing, itchiness, allergy, vulvitis (inflammation of the vulva).

When used as an eye ointment: losing at the website of application, conjunctivitis, trivial punctate keratopathy.

Laboratory abnormalities:

Elevated ALT
Elevated AST
Elevated bilirubin
Anemia
Neutropenia or neutrophilia
Thrombocytopenia  or thrombocytosis
Leukocytosis
Increase in blood vessels urea nitrogen and serum creatinine levels
Hematuria
Side results during maternity and breast-feeding

Acyclovir  can be taken during maternity if the expected effect of therapy exceeds the danger to the unborn infant (no sufficient and totally managed studies on the safety of the medication in expectant mothers have been conducted). Acyclovir  goes through the placenta. Data on the result of maternity in females getting wide spread Acyclovir  in the first trimester of maternity revealed no improve in birth problems in kids compared with the general population. Since the statement included some females, results that Acyclovir  is safe for expectant mothers cannot be regarded as efficient and specified.

Acyclovir  goes into breasts dairy and its content in the dairy is close to its focus in the blood vessels. Children who are breastfed can receive Acyclovir  at full dosage. Given this, Acyclovir  is used in breastfeeding females only when necessary.

Side results in the elderly

Nervous program conditions are the common adverse responses in the seniors.

Overdose

Symptoms: frustration, nerve conditions, difficulty breathing, nausea or nausea, nausea, diarrhoea, renal failing, convulsions, coma.

Warnings and recommendations

During Acyclovir  therapy, it is suggested to take plenty of liquids (in order to avoid sedimentation of Acyclovir  in the renal tubules).

Acyclovir  is not suggested for use in the therapy of kids with poultry pox if the illness is light.

During therapy of vaginal herpes, you should avoid sex or use contraceptives, because Acyclovir  does not avoid transmitting of the malware to the partner.

When getting Acyclovir, you should observe the renal function (checking the level of blood vessels urea nitrogen and serum in the blood vessels plasma).

Acyclovir  and alcohol

Acyclovir is digested in the liver organ by the compound liquor dehydrogenase, which, as its name indicates, results in the breaking of liquor. In sufferers with serious alcohol addiction, breaking of Acyclovir  will be complex, and the chance of adverse responses happening will be higher.